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Anisakiasis : Is raw fish safe to eat? 
 
Anisakiasis is a parasitic nematode infection resulting from eating raw salt-water fish infected with the larval form of Anisakis simplex or Pseudoterranova decipiens.  As sushi, the Japanese delicacy, increasingly become more popular worldwide, this parasitic disease also has become more widespread.  The third stage larvae penetrate into the mucosa of the stomach and intestine resulting in abdominal pain, nausea and vomiting, or diarrhea.  Occasionally the larvae penetrate through the GI tract to other organs forming granulomatous lesions.   Anisakiasis can be easily mistaken for other common gastrointestinal diseases, but should be suspected if the patient had consumed raw or pickled fish shortly prior to the onset of the symptoms.

Anisakis simplex in a 61 year old restaurant owner

Baylisascaris (raccoon roundworm) can cause serious diseases in human

Cerebral baylisascariasis

Botfly (Monsters Inside Me video)

 

Toxocariasis: roundworm parasites in cats and dogs. They can infect you.

The adult roundworms normally live in the small intestine of cats (Toxocara cati) and dogs (Toxocara canis).  It is estimated that, in North America, 20% of adult dogs, 80% of puppies, and 28-42% of cats may be infected.   Embryonated eggs are shed in the feces.  People become infected when these eggs are accidentally ingested through hand to mouth contact.  Children are particularly susceptible as they are often exposed to the eggs on sandboxes and playgrounds contaminated by cat and dog feces.  Following ingestion, larvae are released from the eggs and they penetrate through the intestine, and migrate through the liver, lungs and central nervous system (CNS).  Inflammatory response from the body gives rise to symptoms such as liver enlargement, coughs, wheezing, eosinophilia, lymphadenopathy and fever.  CNS symptoms include meningoencephalitis and seizures.  The larvae eventually stop migrating.  Some die, while others remain viable for months.  Toxocariasis reportedly thrives in poor urban areas as well as in rural areas where house cats and dogs are not as routinely dewormed, and wild cats and dogs serve as a ready reservoir for the parasite.   Diagnosis is by immunoassay with the detection of Toxocara specific antibodies. 

Sources: Hotez PJ, Wilkins PP.  Toxocariasis: America's most common neglected infection of poverty and a helminthiasis of global importance?  PLoS Neglected Tropical Diseases 2009 March 3(3): e400. 

              Hossack J, et al.  A case of adult hepatic toxocariasis.  Nature Clinical Practice gastroenterology & Hepatology 2008. 5: 344-348.

Ocular toxocariasis

Toxoplasmosisprotozoan parasite of cats.  Pregnant women are especially at risk

This is a disease caused by Toxoplasma gondii.   The parasite has 2 distinct life cycles.  The sexual cycle occurs in cats, the normal host, whereas the asexual cycle occurs in human and other mammals such as the rats.  The parasite matures in the intestine of cat, and then are shed in cat feces in the form of oocysts.  Human become infected by accidental ingestion of oocysts, as well as asexual forms of this parasite (tachyzoites and bradyzoites).  Serological surveys indicate that 3-70% of healthy adults in the United States have been infected with T. gondii.   Fetus, newborn, and immunocompromised patients are especially at risk.  The parasite can be passed from the mother to the fetus via the placenta.  Infection can lead to encephalomyelitis, spontaneous abortion, and neonatal deaths.  Many still births may indeed have been caused by undiagnosed toxoplasmosis.  It is recommended that pregnant women stay away from cats during their pregnancy.  Most immunocompetent individuals do not show any symptoms,  However, a minority of them exhibit symptoms that simulate that of more common illnesses, and may include fever, malaise, night sweat, abdominal pain, and myalgia.  In immunocompromised patients, infection may be rapidly progressive and fatal.

Source: Hokelek M.  Toxoplasmosis.  eMedicine.medscape.com.  Updated Jan 27, 2009   

Discovery of toxoplasmosis

Acanthamoeba in brain

Acanthamoeba keratitis

Acanthamoeba infection of the eye

Angiostrongylus cantonensis (Rat lung worm)

Ascaris lumbricoides discovered during colonoscopy

Candiru (toothpick fish)

Cryptosporidium (deadly to those who are immunocompromised)

Entamoeba histolytica (amoebic dysentery)

Filariasis

Guinea worm (Dracunculus medinensis)

Guinea worm - a historical perspective

Leishmaniasis (Leishmania donovani) in Dallas, Texas?

Liver fluke removal

Onchocerca volvulus (African river blindness)

Paragonimus kellicotti (Lung fluke) - Monsters Inside Me video

Pin worms (Enterobius vermicularis) in large intestine.

Schistosoma mansoni, the human blood fluke

Symptoms of blood fluke infection

Strongyloides stercoralis (thread worm)

Tapeworm in canned salmon

Tapeworm segment

Trichuris Trichiura observed during colonoscopy

Trichuris trichiura (the human whipworm)

Trypanosomiasis (African sleeping sickness)

Intraocular cysticercosis

Intraventricular neurocysticercosis

Neurocysticercosis (AnimalPlanet TV)

Neurocysticercosis in a woman

Renal hydatid cyst removal

Q: What is the ultimate solution for our failing health care system?

A: Try not to get sick.